Jochen Eppler, Hans Plesser, Abigail Morrison, Markus Diesmann, Marc-Oliver Gewaltig, "Multithreaded and Distributed Simulation of Large Biological Neuronal Networks", Recent Advances in Parallel Virtual Machine and Message Passing Interface, issue Volume 4757/2007, pp. 391-392, 2007.

To understand the principles of information processing in the brain, we depend on models with more than 10^5 neurons and 10^9 connections. These networks can be described as graphs of threshold elements that exchange point events.